Hemodynamic and metabolic adjustments during exercise and shock avoidance in dogs

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Abstract
Whether the hemodynamic and metabolic consequences of a physical (treadmill exercise) and behavioral (signaled shockavoidance) stress could be differentiated was studied. Direct continuous recordings of cardiac output, systolic and diastolic blood pressure and discrete determinations of the arterial-mixed venous O2 ((a-v)O2) content difference were analyzed in 6 dogs during exposure to 3 grades of treadmill exercise and when working on a shock-avoidance task. In 5 animals the relationship between cardiac output and the (a-v)O2 difference during shock-avoidance conditioning was significantly different from the pattern seen during exercise. In 4 animals, avoidance conditioning relative to exercise stress elicited overperfusion. Behavioral stress produced elevation in diastolic and systolic blood pressure. Compared to physical stress behavioral stress can produce a dissociation of cardiovascular and metabolic processes in the presence of acute pressor responses.

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