A STUDY OF THE HISTOPATHOLOGY AND PHYSIOLOGIC FUNCTION OF THYROID TUMORS, USING RADIOACTIVE IODINE AND RADIOAUTOGRAPHY*†

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Abstract
AT THE meeting of this Society one year ago we presented some observations (1) on the capacity of various types of thyroid tumors to collect radioiodine and briefly reviewed the pertinent literature dealing with the iodine and radioiodine content of such tissues. Our former observations were made by digesting known weights of thyroid tissue and counting the radioactivity in the iodine which was precipitated from the liquid digest. We found that undifferentiated tumors in general showed relatively less avidity for radioiodine than some more differentiated ones. We also found, in that group, a few benign tumors which contained more of an administered dose of radioiodine per unit weight than the remaining thyroid tissue. Shortly before our report was given, Leblond et al. (2) and Puppel, Leblond and Curtis (3) reported that all nodules in 7 cases of nodular goiter contained less radioiodine and were therefore functionally less active than the remaining thyroid tissue.