Diversification of Monoterpene Indole Alkaloid Analogs through Cross-Coupling
- 28 May 2013
- journal article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 15 (11) , 2850-2853
- https://doi.org/10.1021/ol401179k
Abstract
Catharanthus roseus monoterpene indole alkaloid analogs have been produced via a combination of biosynthetic and chemical strategies. Specifically, introduction of a chemical handle—a chlorine or a bromine—into the target molecule by mutasynthesis, followed by postbiosynthetic chemical derivatization using Pd-catalyzed Suzuki-Miyaura cross-coupling reactions robustly afforded aryl and heteroaryl analogs of these alkaloids.Keywords
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