While Tinkering With the β-Cell… Metabolic Regulatory Mechanisms and New Therapeutic Strategies
- 1 November 2002
- journal article
- Published by American Diabetes Association in Diabetes
- Vol. 51 (11) , 3141-3150
- https://doi.org/10.2337/diabetes.51.11.3141
Abstract
A common feature of the two major forms of human diabetes is the partial or complete loss of insulin secretion from β-cells in the pancreatic islets of Langerhans. In this article, we review the development of a set of tools for studying β-cell biology and their application to understanding of fuel-mediated insulin secretion and enhancement of β-cell survival. Insights into these basic issues are likely to be useful for the design of new drug and cell-based diabetes therapies.Keywords
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