Synthesis and antiinflammatory activity of [(cycloalkylmethyl)phenyl]acetic acids and related compounds

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Abstract
[(Cycloalkylmethyl)phenyl]acetic acid derivatives and related compounds were synthesized to test their antiinflammatory and analgesic activities. Some of the compounds in this series had good activity in the carrageenan edema test. Among them, sodium 2-[4-[(2-oxocyclopentyl)methyl]phenyl]propionate dihydrate and 2-[4-[(2-oxocyclohexylidene)methyl]phenyl]propionic acid showed potent analgesic and antiadjuvant arthritis activities with excellent antipyretic properties.