Human Forearm Muscle Metabolism during Exercise III Uptake, release and oxidation ofβ-hydroxybutyrate and observations on theβ-hydroxybutyrate/acetoacetate ratio

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Abstract
The metabolism of ketone bodies by human forearm muscle during exercise was studied in healthy young volunteers. Net muscular uptakes of β-hydroxybutyrate and acetoacetate were observed at rest. The arterial-deep venous concentration differences of both these metabolites correlated positively to their arterial concentrations at rest. No correlation between β-hydroxybutyrate uptake and arterial concentration was observed during exercise. Results using DL-β-hydroxybutyrate-4-14C as tracer during exercise indicated that the L(+) isomer was taken up to a lesser extent than the D(-) isomer. During arterial infusion of D(-)-β-hydroxybutyrate-3-14C, the deep venous β-hydroxybutyrate specific activity was lower than that of arterial blood, indicating that an intramuscular production of β-hydroxybutyrate occurred during exercise. Net production of acetoacetate and/or β-hydroxybutyrate by the forearm muscle was observed in five of seven experiments.

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