METABOLISM OF CALCIUM AND MAGNESIUM IN LIVER DURING ACUTE THIOACETAMIDE INTOXICATION

  • 1 January 1976
    • journal article
    • research article
    • Vol. 14  (2) , 101-108
Abstract
The metabolism of Ca and Mg in liver of thioacetamide treated rats was studied. A change in the semipermeability of the cell membrane to Ca, Mg, Na and K was observed. The variations in the concentration of extra- and intracellular cations indicates that an undiscriminated in- and outflux of these ions takes place at the time of highest Ca deposition. This change in cell membrane permeability seems to be related to modifications in phospholipid metabolism. An increased incorporation of 32P into the acidic phospholipids (phosphatidyl ethanolamine and phosphatidyl serine) suggests their involvement in the physiological changes of the cell membrane. The results also show the existence of a hormonally determined susceptibility of the cell membrane to undergo those changes during carcinogenesis.

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