LIVER TUMORS INDUCED BY 4-DIMETHYLAMINOAZOBENZENE - EXPERIMENTAL BASIS FOR A CHEMICAL CARCINOGENESIS CONCEPT
- 1 January 1976
- journal article
- research article
- Vol. 46 (8) , 639-656
Abstract
In rats fed 4-dimethylaminoazobenzene modifications in the distribution of extracellular and intracellular cations in liver were noted. The correlation between cell ionic permeability changes and the induction of cholangiocarcinoma or hepatoma was analyzed in the light of histological and biochemical findings. A new concept of chemical carcinogenesis is stated in which the increase of passive Ca2+ influx produces mitochondrial damage associated with permanent modifications of the structural and functional characteristics of the cell membranes as well as of the genetic mechanisms controlling cell division.This publication has 11 references indexed in Scilit:
- The ionic structure of lecithin monolayersJournal of Lipid Research, 1967
- CALCIUM AND MAGNESIUM CONTENT OF RAT LIVER AND MORRIS HEPATOMA 5123 TC1967
- FINE STRUCTURAL ALTERATIONS IN CELL PARTICLES DURING CHEMICAL CARCINOGENESISThe Journal of cell biology, 1961
- ON IN VITRO RELEASE OF CYTOPLASMIC ENZYMES FROM ASCITES TUMOR CELLS AS COMPARED WITH STRAIN L CELLS1961
- Phospholipids. 4. On the composition of hen's egg phospholipidsBiochemical Journal, 1957
- CERTAIN EFFECTS OF PARA-DIMETHYLAMINOAZOBENZENE, DEFICIENT DIET, AND HYPOTONIC MEDIA ON MITOCHONDRIAL ENZYMES IN EXPERIMENTAL RAT-LIVER CARCINOGENESIS1956
- PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENTJournal of Biological Chemistry, 1951
- STUDIES ON THE INTRACELLULAR COMPOSITION OF LIVER AND LIVER TUMOR FROM RATS FED 4-DIMETHYLAMINOAZOBENZENE1949
- THE INTRACELLULAR DISTRIBUTION OF PROTEIN, NUCLEIC ACIDS, RIBOFLAVIN, AND PROTEIN-BOUND AMINOAZO DYE IN THE LIVERS OF RATS FED p-DIMETHYLAMINOAZOBENZENEJournal of Biological Chemistry, 1948
- INTRACELLULAR DISTRIBUTION OF ENZYMES .2. THE DISTRIBUTION OF SUCCINIC DEHYDROGENASE, CYTOCHROME OXIDASE, ADENOSINETRIPHOSPHATASE, AND PHOSPHORUS COMPOUNDS IN NORMAL RAT LIVER AND IN RAT HEPATOMAS1946