How Y chromosomes become genetically inert.
- 15 June 1993
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 90 (12) , 5737-5741
- https://doi.org/10.1073/pnas.90.12.5737
Abstract
We have investigated the mechanistic aspects of inactivation of the major larval cuticle protein genes (Lcp1-4) in Drosophila miranda during Y chromosome evolution. The Lcp genes are located on the X2 and neo-Y chromosomes in D. miranda but are autosomally inherited in all other Drosophila species investigated so far. In the neo-Y chromosome all four Lcp loci are embedded within a dense cluster of transposable elements. The X2 Lcp1-4 loci are expressed, while the Y chromosomal Lcp3 locus shows only reduced activity and the Lcp1, Lcp2, and Lcp4 are completely inactive. Our results suggest that Lcp1 and Lcp3 loci on the degenerating Y chromosome of D. miranda are silenced by neighboring transposable elements. These observations support our assumption that the first step in Y chromosome degeneration is the successive silencing of Y chromosomal loci caused by trapping and accumulation of transposons.Keywords
This publication has 21 references indexed in Scilit:
- A position-effect assay for boundaries of higher order chromosomal domainsPublished by Elsevier ,1991
- The Evolution of Sex ChromosomesScience, 1991
- Position-effect variegation after 60 yearsTrends in Genetics, 1990
- A structural basis for variegating position effectsCell, 1984
- Homothallic switching of yeast mating type cassettes is initiated by a double-stranded cut in the MAT locusCell, 1982
- Genetic Transformation of Drosophila with Transposable Element VectorsScience, 1982
- The regulation of yeast mating-type chromatin structure by SIR: An action at a distance affecting both transcription and transpositionCell, 1982
- Cuticle protein genes of Drosophila: Structure, organization and evolution of four clustered genesCell, 1982
- The cuticle genes of Drosophila: A developmentally regulated gene clusterCell, 1981
- TRANSPOSABLE ELEMENTS IN DROSOPHILA AND OTHER DIPTERAAnnual Review of Genetics, 1980