Antitumor effect of oral cisplatin on certain murine tumors.

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Abstract
The comparative antitumor effects of cisplatin were investigated against several murine tumors after i.p., i.v., and oral administrations. A single administration of cisplatin could significantly inhibit the growth of both L1210 and P388 leukemias, and EL-LP-12 tumors under the conditions used. Oral cisplatin was tested against EL-LP-12 in combination with 6 other antitumor drugs. Cisplatin was inhibitory in binary combination with mitomycin C, vinblastine, 5-fluorouracil, carmustine (BCNU), and cyclophosphamide. In particular, the drug combined with either BCNU or cyclophosphamide showed marked therapeutic synergism.