Immunoglobulin substitution therapy in a patient with primary hypogammaglobulinaemia and anti-IgA antibodies

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Abstract
Permanent immunoglobulin substitution therapy was performed in a 44‐year‐old patient with common variable immunodeficiency, recurrent respiratory tract infections, total absence of serum IgA and a high titre of class‐specific anti‐IgA antibodies. An IgA‐depleted i.v. immunoglobulin (IG) preparation was used. Infusions were well tolerated by the patient although minor anaphylactoid symptoms regularly occurred. Anti‐IgA antibody titres rose during the first 4 months of treatment and gradually fell during the following 8 months. Regular IG substitution therapy led to a substantial improvement in the patient's health and quality of life.