Direct Stimulation of Translation by the Multifunctional Herpesvirus ICP27 Protein
- 1 February 2006
- journal article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 80 (3) , 1588-1591
- https://doi.org/10.1128/jvi.80.3.1588-1591.2006
Abstract
Herpes simplex virus type 1 (HSV-1) ICP27 protein is an essential regulator of viral gene expression with roles at various levels of RNA metabolism in the nucleus. Using the tethered function assay, we showed a cytoplasmic activity for ICP27 in directly enhancing mRNA translation in vivo in the absence of other viral factors. The region of ICP27 required for translational stimulation maps to the C terminus. Furthermore, in infected cells, ICP27 is associated with polyribosomes, indicating a function in translation during the lytic cycle.Keywords
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