Effect of Antiorthostatic Suspension on Interferon- / Production by the Mouse
- 1 November 1984
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 177 (2) , 253-256
- https://doi.org/10.3181/00379727-177-41939
Abstract
Mice were suspended in a model that simulates weightlessness that occurs during prolonged space flight. After 1 and 2 wk of suspension in an antiorthostatic (head-down tilt) position, the mice were challenged with polyriboinosinic-polyribocytidylic acid to induce interferon-.alpha./.beta.. Interferon production was severely reduced in mice that were suspended. When mice were allowed to recover in cages for a week following removal from suspension, they recovered their full interferon-production capacity. Mice suspended in an orthostatic (horizontal) position did not have their interferon production capabilities affected, which indicates that stress per se was not a major component in the effects of antiorthostatic suspension on interferon induction.This publication has 1 reference indexed in Scilit:
- Model for antiorthostatic hypokinesia: head-down tilt effects on water and salt excretionJournal of Applied Physiology, 1980