NONEXCRETION OF SERUM ALKALINE PHOSPHATASE BY THE LIVER AND THE PANCREAS OF NORMAL DOGS

Abstract
The increase in serum alkaline phosphatase caused by transfusion of serum from a dog with common bile duct obstruction to a normal dog does not result in an elevation of the output of alkaline phosphatase in the bile or pancreatic juice of the recipient. This finding indicates that the serum alkaline phosphatase is not excreted by the liver or pancreas and that the phosphatase which appears in the bile and pancreatic juice is formed by the secretory cells of these organs.