POSITIVE INTERACTIONS BETWEEN HUMAN INTERFERON AND CYCLOPHOSPHAMIDE OR ADRIAMYCIN IN A HUMAN-TUMOR MODEL SYSTEM

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  • 1 January 1984
    • journal article
    • research article
    • Vol. 44  (3) , 904-908
Abstract
Human lymphoblastoid interferon strongly increased the antitumor activity of suboptimal doses of 2 commonly used anticancer drugs, cyclophosphamide and Adriamycin, on a human breast tumor xenograft growing in nude mice. A combination of human lymphoblastoid interferon with either agent caused regression and in some cases total disappearance of tumros at doses of drug and interferon that, used singly, were capable only of inhibiting tumor growth. The combined therapy also resulted in a greatly increased survival. Studies with interferon and cyclophosphamide indicated that the antitumor activity was greatest when the 2 agents were administered simultaneously rather than sequentially.