Involvement of hysteretic effects in the inhibition of carnitine palmitoyltransferase by malonyl-CoA

15 December 1984

journal article
research article
Published by Portland Press Ltd. in Biochemical Journal

Vol. 224 (3) , 1015-1018
https://doi.org/10.1042/bj2241015

Abstract

Carnitine palmitoyltransferase in its normal mitochondrial environment behaves as a hysteretic enzyme, exhibiting slow changes in reaction rate after the addition of oleoyl-CoA or malonyl-CoA. Reaction rates become constant after a short time, but the sensitivity of the enzyme from fed rats to the inhibition by malonyl-CoA remains much greater than that of starved rats.

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