Effect of Ascorbic Acid on Diabetogenic Action of Alloxan

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Abstract
When 100 mg. of alloxan/Kg. were injected intraperitoneally in rats, diabetes was produced in 5 of 29 animals studied. If 50 mg. of ascorbic acid were administered intraven. onemin. before the alloxan, 9 of 19 animals studied became diabetic. d-Isoascorbic acid when administered under similar conditions as ascorbic acid did not potentiate the effect of alloxan. The possibility of alloxan and ascorbic acid forming a diabetogenic complex was investigated by injecting intraperitoneally a mixture of ascorbic acid and alloxan. In 5 of the animals studied there was no diabetes. The ascorbic acid has to be injected within a few min. before the alloxan to potentiate the diabetogenic action of alloxan.