Lithium Toxicity Enhanced by Diuresis

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Abstract
To the Editor: The role of sodium depletion in the production of lithium intoxication among chronic users of lithium carbonate is well documented.1 2 3 The mechanism of this interaction between sodium and lithium ions relates to the similarity of reabsorption at the proximal renal tubule. Therefore, in the face of dietary restriction of sodium intake, reabsorption at the proximal tubule is enhanced, and both sodium and lithium ions are maximally conserved. The syndrome of lithium intoxication was well known in the late 1940's,4 , 5 when lithium chloride was first introduced as a substitute for table salt. Now that lithium (carbonate) has become . . .

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