High p27Kip1 Expression Predicts Superior Relapse-Free and Overall Survival for Premenopausal Women With Early-Stage Breast Cancer Receiving Adjuvant Treatment With Tamoxifen Plus Goserelin
- 1 October 2003
- journal article
- breast cancer
- Published by American Society of Clinical Oncology (ASCO) in Journal of Clinical Oncology
- Vol. 21 (19) , 3594-3600
- https://doi.org/10.1200/jco.2003.02.021
Abstract
Purpose: To determine the predictive value of p27Kip1 in premenopausal women with early-stage hormone receptor–positive breast cancer. Patients and Methods: We retrospectively examined tumor specim...Keywords
This publication has 30 references indexed in Scilit:
- CDK inhibitors: positive and negative regulators of G1-phase progressionGenes & Development, 1999
- The p21Cip1 and p27Kip1 CDK `inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblastsThe EMBO Journal, 1999
- Cleavage of p21Cip1/Waf1 and p27Kip1 Mediates Apoptosis in Endothelial Cells through Activation of Cdk2: Role of a Caspase CascadeMolecular Cell, 1998
- New functional activities for the p21 family of CDK inhibitors.Genes & Development, 1997
- Cancer Cell CyclesScience, 1996
- Inhibitors of mammalian G1 cyclin-dependent kinases.Genes & Development, 1995
- p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene.Genes & Development, 1995
- Principles of CDK regulationNature, 1995
- Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signalsCell, 1994
- p21 is a universal inhibitor of cyclin kinasesNature, 1993