Aspirin aggravates the degeneration of canine joint cartilage caused by immobilization

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Abstract
The effect of aspirin on the degeneration of knee cartilage caused by immobilization was examined. If dogs were fed aspirin daily (serum salicylate = 20–25 mg/dl) for 6 weeks while one hind limb was immobilized in a cast, the decreases in uronic acid content and net proteoglycan synthesis in cartilage from the immobilized knee were significantly greater than the decreases in cartilage from immobilized knees of dogs that had not received aspirin (P35S‐proteoglycans present in the culture medium was nearly twice that from cultures of cartilage of the contralateral knee. Also, more than twice as many of the total tissue proteoglycans (uronic acid) were extractable with 0.4M guanidinium chloride, a nondissociating solvent (PP<0.01).
Funding Information
  • National Institute of Arthritis ((AM 20582 and AM 27075))