Studies on WB-3559 A,B,C and D, new potent fibrinolytic agents. I. Discovery, identification, isolation and characterization.
- 1 January 1985
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 38 (11) , 1469-1475
- https://doi.org/10.7164/antibiotics.38.1469
Abstract
WB-3559 A, B, C and D were produced by a bacterium which was classified as a member of the genus Flavobacterium. These compounds were purified by solvent extraction followed by chromatography on silica gel and then isolated by HPLC. The chemical structures were determined on the basis of chemical and spectroscopic evidence as in the succeeding papers. WB-3559 A, B, C and D stimulated rabbit plasma euglobulin clot lysis time. A chemically synthesized compound (WB-3559 D-syn) stimulated mouse plasma euglobulin clot lysis time when injected intravenously.This publication has 4 references indexed in Scilit:
- Studies on WB-3559 A,B,C and D, new potent fibrinolytic agents. II. Structure elucidation and synthesis.The Journal of Antibiotics, 1985
- Studies on WF-5239, a new potent platelet aggregation inhibitor.The Journal of Antibiotics, 1984
- Studies on new antiplatelet agents, WS-30581 A and B.The Journal of Antibiotics, 1984
- The Binding of Diiodosalicylate and Flufenamate to the Plasma Antiactivator: Analysis of Chemical FibrinolysisThrombosis and Haemostasis, 1979