In Vitro Characterization of MAT LyLu: A Dunning Rat Prostate Adenocarcinoma Tumor Subline

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Abstract
Prostate carcinoma has been a therapeutic challenge. The Dunning tumor, a rat prostate adenocarcinoma tumor model was used to evaluate prostate carcinoma treatment protocols. The Dunning tumor subline, MAT LyLu, as described in this report, was established and characterized as an in vitro continuous cell culture. The cell culture was stable for > 60 passages. The in vitro characteristics of the MAT LyLu cell culture, such as growth rate, loss of contact inhibition, clonogenicity, morphology and tumorigenicity, are consistent with the malignant characteristics of the Dunning tumor subline. The MAT LyLu cell culture has enzyme activities which can be used to characterize the cell line. The establishment of MAT LyLu as a continuous cell culture should provide a controlled approach to evaluate the etiology and treatment of prostate carcinoma.