Effects of Calcium Channel Activators on the Response of Rabbit Aortic Rings to Alpha1-Receptor Agonists: Evidence for Two Modes of Action

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Abstract
The interaction between activators of the calcium channel and the α1-adrenoceptor has been studied in isolated rabbit aortic rings. The data obtained in these investigations are not consistent with the idea of a homogenous population of α1-receptors which trigger contraction via a single pathway. Our results suggest that calcium channel activators reveal two modes of spasmogenic action for α1-adrenoceptor agonists. Furthermore, we have shown that there may be multiple drug recognition sites on the α1-receptor.