The thyroglobulin gene resides on chromosome 8 in man and on chromosome 7 in the rat
- 1 January 1985
- journal article
- research article
- Published by S. Karger AG in Cytogenetic and Genome Research
- Vol. 39 (2) , 150-153
- https://doi.org/10.1159/000132125
Abstract
Human chromosomes were separated by a dual laser FACS sorter and their DNA hybridized with a thyroglobulin gene probe. A strong hybridization signal was obtained with DNA from chromosome 8. A panel of mouse-rat cell hybrids was used to determine the chromosomal localization of the rat thyroglobulin gene by the Southern blotting method. Comparison of the cytogenetic data with the hybridization signals obtained with the rat thyroglobulin probe allowed assignment of this gene to rat chromosome 7. It is concluded that the synteny relationship between the thyroglobulin gene and the c-myc oncogene has been conserved in rat and man.Keywords
This publication has 10 references indexed in Scilit:
- High-Resolution Chromosome Sorting and DNA Spot-Blot Analysis Assign McArdle's Syndrome to Chromosome 11Science, 1984
- Structural organization of the 5′ region of the human thyroglobulin geneEuropean Journal of Biochemistry, 1984
- Gene mapping in the rat by mouse-rat somatic cell hybridization: synteny of the albumin and α-fetoprotein genes and assignment to chromosome 14Cytogenetic and Genome Research, 1984
- Mouse c-myc Oncogene Is Located on Chromosome 15 and Translocated to Chromosome 12 in PlasmacytomasScience, 1982
- Two human c-onc genes are located on the long arm of chromosome 8.Proceedings of the National Academy of Sciences, 1982
- Design and operation of a dual laser chromosome sorterCytometry, 1982
- Isolation and characterization of a fragment of rat thyroglobulin geneBiochemical and Biophysical Research Communications, 1982
- Cloning of Four DNA Fragments Complementary to Human Thyroglobulin Messenger RNAEuropean Journal of Biochemistry, 1981
- Control of serum protein production in hepatocyte hybridomas: immortalization and expression of normal hepatocyte genes.Proceedings of the National Academy of Sciences, 1980
- EFFECTS OF COUNTERSTAINING WITH DNA-BINDING DRUGS ON FLUORESCENT BANDING-PATTERNS OF HUMAN AND MAMMALIAN CHROMOSOMES1980