DABCO-Mediated Synthesis and Biological Activity of Cyanohydrin Esters
- 1 June 1990
- journal article
- Published by Oxford University Press (OUP) in Bulletin of the Chemical Society of Japan
- Vol. 63 (6) , 1807-1810
- https://doi.org/10.1246/bcsj.63.1807
Abstract
Cyanohydrin esters 1–31 have been prepared from α-ketonitriles and aldehydes using DABCO (1,4-diazabicyclo[2.2.2] octane) as nucleophilic acylation catalyst. The modified piperonal 8 was found to inhibit the formation of thromboxane synthetase.Keywords
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