Studies on cerebral sphingomyelin

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Abstract
Acid hydrolysis of cerebral phospholipids which are stable to mild acid and alkali hydrolysis has confirmed that sphingomyelin represents only a proportion of this fraction whereas the nature of the remainder is unknown. Sphingomyelin has been determined in the brain tissue of rats and other species and the results compared with those obtained with other methods. The concentration of true sphingomyelin in rat brain reaches its peak 9-11 weeks after birth. The incorporation of labelled phosphate into rat-brain sphingomyelin reached a constant level after 9 weeks. This metabolism was largely confined to sphingomyelin found in the grey matter.