IMMUNOLOGICAL CROSS-REACTIVITY OF ENTEROTOXINS OF AEROMONAS-HYDROPHILA AND CHOLERA-TOXIN

  • 1 January 1982
    • journal article
    • research article
    • Vol. 47  (1) , 34-42
Abstract
Pre-incubation with anticholera toxin (ACT) significantly reduced intestinal secretion induced by cell-free broth preparations of heat-labile toxins (LT) of Escherichia coli and A. hydrophila in jejunal perfusion experiments in rats in vivo. Pre-incubation with ACT also prevented cytotoxicity by E. coli LT in the mouse Y1 cell culture system. Pre-incubation had no effect on cytotoxicity in mouse Y1 and L132 cell lines or on hemolytic activity with cell-free preparations of A. hydrophila. Rats were immunized with cholera toxin given as an i.p. priming dose followed 12 days later by intraduodenal boosting. Immunization significantly protected against net intestinal fluid secretion induced by enterotoxigenic E. coli and A. hydrophila and by cholera toxin.