Comparative penetration of six antibiotics into the cerebrospinal fluid of rabbits with experimental staphylococcal meningitis

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Abstract
This study compared the penetration of six antistaphylococcal antibiotics into the cerebrospinal fluid (CSF) of rabbits with experimental staphylococcal meningitis. Six to nine animals were treated with each antibiotic. Serum and CSF antibiotic concentrations were obtained at 2, 4, 6 and 8 h; and per cent penetration (CSF concentration/Serum concentration × 100%) values were calculated for each drug at these times. The mean per cent penetration values of vancomycin, (range 8.4 to 11.7%) were significantly higher than those of oxacillin (range 1.0 to 2.8%), nafcillin (range 1.4 to 2.0%), and cephalothin (range 1.4 to 2.1%). The mean penetration values of cephradine (range 5.6 to 7.7%) and methicillin (range 3.6 to 5.9%) were intermediate, and they did not differ statistically from those of the other antibiotics.