Modification of Radiosensitivity of Genetically Anemic Mice by Implantation of Blood-Forming Tissue

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Abstract
The dependence of acute radiation sensitivity on the genotypes of the functioning blood-forming tissue has been demonstrated by testing the radiation reaction of WWV anemic mice successfully implanted with isologous normal ww blood-forming tissue. The LD50/30 values of such mice is raised from approximately 250 r to about 680 r, a figure approaching the level of normal ww Individuals. Modification of radiation sensitivity of carriers of mutant alleles of the W-series in a single dose (WVW and Ww) has also been achieved by implantation. In each case the LD50 value is increased to a level characteristic of normal mice of this strain. Thus, in the W-series anemias the acute radiosensitivity of the entire organism is, in large measure, dependent on the genetic constitution of the cells residing in the marrow.