Alloxan-Induced Azotemia in the Rat.

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Abstract
Groups of from 6-13 rats were given doses of alloxan ranging from 150 mg.[long dash]450 mg./kg. The minimum dose which produced hyperglycemia also produced azotemia. When azotemia was present the blood urea, uric acid, and creatinine N were all elevated. For example, 72 hrs. after 400 rag. of alloxan/kg. the mean blood glucose was 736 rng. % while the urea, uric acid, and creatinine nitrogens were 165 mg. %, 3.2 mg. % and 6.7 mg. % respectively. The simultaneous admn. of insulin prevented the hyperglycemia but not the azotemia. In animals with persistent diabetes the NPN returned to normal in most cases.

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