Total Synthesis of (±)-Jiadifenin, a Non-peptidyl Neurotrophic Modulator
- 16 October 2004
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 126 (44) , 14358-14359
- https://doi.org/10.1021/ja045939p
Abstract
We report the first total synthesis of jiadifenin (1), the establishment of a modality for its biological evaluation, and the discovery of apparently more potent neurotrophic activity in fully synthetic compound 17, an intermediate en route to 1.Keywords
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