Serotonin 5-HT3 receptor binding kinetics in the cortex of suicide victims are normal

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Abstract
Summary Serotonergic abnormalities have been identified in the brain of suicide victims independent of psychiatric diagnosis. We report the first study of serotonin 5-HT3 receptors in the brain of suicide victims. There were no differences in the number (Bmax) or affinity (K d ) of 5-HT3 receptors in the temporal cortex of suicide victims compared to matched controls. There was a negative correlation between brain serotonin levels and receptor number (r=−0.5, p=0.04) in both groups. This study indicates that alterations in serotonergic function in the brain of suicide victims do not appear to directly involve the 5-HT3 receptor.