Tetanus Toxin: Fine Structure Localization of Binding Sites in Striated Muscle
- 9 February 1968
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 159 (3815) , 643-644
- https://doi.org/10.1126/science.159.3815.643
Abstract
When striated muscle from mice poisoned with purified tetanus neurotoxin was incubated with tetanus antitoxin labeled with horseradish peroxidase and stained for peroxidase activity, an electron-opaque reaction product was found in the transverse and terminal sacs of the longitudinal elements of the sarcotubular system. Demonstration of toxin in this location suggests that it acts by interfering with contraction coupling or mechanisms of contraction-relaxation.This publication has 8 references indexed in Scilit:
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