CAPILLARY PERMEABILITY AND THE ADRENAL CORTEX STUDIES OF CERVICAL LYMPH IN THE ADRENALECTOMIZED DOG

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Abstract
Lymph was collected from the cervical trunk of normal and adrenalectomized dogs under local anesthesia. The protein content of the lymph of the normal animals averaged 2.8 g./100 cc., and of the adrenalectomized 4.3 g. The increase above normal was as great in the dogs in moderate as in severe insufficiency and was not merely an accompaniment of a moribund state. The finding offers direct evidence of an increase in capillary permeability in 1 region of the dog in adrenal insufficiency. The significance of this protein increase in lymph to the osmotic equilibrium between blood plasma and extracellular fluid is discussed. The flow of lymph was in general, but not consistently, reduced in insufficiency. The extracellular fluid vol., measured by means of thiocyanate, was increased as well as decreased.

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