Enhancement of sulfanilamide N4-hydroxylase activity in kidney and liver microsomes of rats by pretreatment with 3-methylcholanthrene type-polychlorinated biphenyl.
- 1 January 1982
- journal article
- research article
- Published by Pharmaceutical Society of Japan in Journal of Pharmacobio-Dynamics
- Vol. 5 (11) , 853-858
- https://doi.org/10.1248/bpb1978.5.853
Abstract
N4-hydroxylation of sulfanilamide was studied with kidney and liver microsomes of rats by means of high-performance chromatography. In kidney microsomes, both the contents of cytochrome P-450 (448) and the activity of N4-hydroxylase were markedly increased by pretreatment with 3,4,5,3'',4''-pentachlorobiphenyl (PenCB) (.apprx. 4 times), although neither one was increased by 3-methylcholanthrene (3-MC) and phenobarbital (PB) pretreatments. In liver microsomes, both N4-hydroxylase activity and cytochrome P-450 (448) contents were increased by PenCB or 3-MC pretreatment, whereas by PB pretreatment N4-hydroxylase activity was not changed, although cytochrome P-450 contents was increased 2-fold.This publication has 11 references indexed in Scilit:
- Experimental Studies on the Antigenicity of Some Metabolites and Related Compounds of SulfanilamideYAKUGAKU ZASSHI, 1979
- METABOLISM OF [P-O-18]-PHENACETIN - MECHANISM OF ACTIVATION OF PHENACETIN TO REACTIVE METABOLITES IN HAMSTERS1979
- Selective induction of rat liver microsomal cytochrome P-448 by 3,4,5,3',4'-pentachlorobiphenyl and its effect on liver microsomal drug metabolism.Journal of Pharmacobio-Dynamics, 1979
- Inductive effect of polychlorinated biphenyls mixture and individual isomers on the hepatic microsomal enzymes.CHEMICAL & PHARMACEUTICAL BULLETIN, 1978
- Separation of pure polychlorinated biphenyl isomers into two types of inducers on the basis of induction of cytochrome P-450 or P-448Chemico-Biological Interactions, 1977
- Positive Skin Reaction Induced by 4,4′-Azoxybenzenedisulfonamide in Relationship to the Sulfanilamide AllergyInternational Archives of Allergy and Immunology, 1977
- N-Hydroxylierung von Sulfanilamid zu p-Hydroxylaminobenzolsulfonamid durch LebermikrosomenNaunyn-Schmiedeberg's Archives of Pharmacology, 1965
- The Carbon Monoxide-binding Pigment of Liver MicrosomesJournal of Biological Chemistry, 1964
- N-HYDROXY-2-ACETYLAMINOFLUORENE - A METABOLITE OF 2-ACETYLAMINOFLUORENE WITH INCREASED CARCINOGENIC ACTIVITY IN RAT1961
- PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENTJournal of Biological Chemistry, 1951