The Effect of the Administration of Acid and Alkaline Salts Upon the Ascorbic Acid Content of Guinea Pig Tissues

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Abstract
In a previous study the authors observed a definite relationship, in humans, between the amount of ascorbic acid found in the urine and the hydrogen ion concentration of the latter. Observations in guinea pigs show that the administration of sodium bicarbonate in amounts sufficient to result in a highly alkaline urine results in an increased concentration of ascorbic acid in the adrenals and liver. It is shown that increased retention of ascorbic acid in the tissues may be at least a partial explanation of the decreased urinary output of ascorbic acid observed in humans in whom the urine had been rendered alkaline by the administration of sodium bicarbonate.