DECREASED VASCULAR REACTIONS TO PERMEABILITY FACTORS IN EXPERIMENTAL DIABETES

  • 1 January 1976
    • journal article
    • research article
    • Vol. 57  (6) , 747-754
Abstract
Light microscopic and EM studies showed that blood vessels of the cremaster muscle of alloxan-diabetic rats under the local influence of histamine or serotonin presented less labeling by colloidal C, previously injected i.v., than vessels of normal rats. The hyporeactive state of these vessels was promptly reversed to normal conditions by the administration of insulin. Insulin also potentiated leakage of C particles in the vessels of normal animals. Insulin might be involved in vascular events following injury and decreased levels of the hormone, as occurring in diabetes, might result in decreased inflammatory reactions.