Blood dendritic cells in patients with acute lymphoblastic leukaemia
- 12 May 2004
- journal article
- research article
- Published by Wiley in British Journal of Haematology
- Vol. 126 (1) , 77-80
- https://doi.org/10.1111/j.1365-2141.2004.04989.x
Abstract
Myeloid and plasmacytoid dendritic cells (MDCs, PDCs) play a key role in the initiation of immune responses. In this study, we show a severe reduction of MDCs and PDCs in patients with B lineage acute lymphoblastic leukaemia (B-ALL; P = 0.01 vs. controls). DCs from patients with T lineage ALL (T-ALL) were quantitatively and functionally comparable to healthy donors, as demonstrated by secretion of interleukin (IL)-12p70 and interferon-alpha. In vitro, the circulating CD34(+) fraction of B-ALL cases did not generate either CD1a(+) MDCs or PDCs, suggesting that DC development is probably affected in B-ALL, but not in T-ALL.Keywords
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