Absence of Antibody Plaque Forming Cells in Spleens of Thymectomized Mice Immunized with Sheep Erythrocytes.

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Abstract
Summary Surgical removal of the thymus of newborn NIH mice resulted in a marked suppression in subsequent ability to form circulating serum hemolysins to sheep erythrocytes. Spleen cell suspensions from young adult mice thymectomized at birth and immunized with sheep red blood cells were markedly less capable of forming hemolytic antibody plaques in agar gel than spleen cells from sham operated control mice. Although the number of antibody plaques formed by cells from thymectomized mice was markedly reduced, the size of individual plaques was generally similar to those formed by spleen cells from the control mice.

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