Discordant Resistance to Kanamycin and Amikacin in Drug-Resistant Mycobacterium tuberculosis
- 1 September 2003
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 47 (9) , 2971-2973
- https://doi.org/10.1128/aac.47.9.2971-2973.2003
Abstract
It is generally thought that there is full cross-resistance in Mycobacterium tuberculosis between the aminoglycoside drugs kanamycin and amikacin. However, kanamycin resistance and amikacin susceptibility were seen in 43 of 79 (54%) multidrug-resistant Estonian isolates, indicating that there might be a need to test the resistance of M. tuberculosis isolates to both drugs.Keywords
This publication has 24 references indexed in Scilit:
- Sequence Polymorphism in the rrs Gene of Mycobacterium tuberculosis Is Deeply Rooted within an Evolutionary Clade and Is Not Associated with Streptomycin ResistanceJournal of Clinical Microbiology, 2001
- Molecular genetic basis of antimicrobial agent resistance inMycobacterium tuberculosis: 1998 updateTubercle and Lung Disease, 1998
- Geographic variation of the predictive values of genomic mutations associated with streptomycin resistance inMycobacterium tuberculosisMolecular and Cellular Probes, 1997
- Resistance to drugs targeting protein synthesis in mycobacteriaTrends in Microbiology, 1994
- Molecular basis of streptomycin resistance in Mycobacterium tuberculosis: alterations of the ribosomal protein S12 gene and point mutations within a functional 16S ribosomal RNA pseudoknotMolecular Microbiology, 1993
- Susceptibility of streptomycin-resistantMycobacterium tuberculosis strains to amikacinEuropean Journal of Clinical Microbiology & Infectious Diseases, 1988
- Interaction of antibiotics with functional sites in 16S ribosomal RNANature, 1987
- Cross-resistance in M. tuberculosis to kanamycin, capreomycin and viomycinTubercle, 1977
- Cross-resistance Relationships among the Aminoglucoside Antibiotics in Mycobacterium tuberculosisJournal of General Microbiology, 1975
- IN VITRO AND IN VIVO LABORATORY STUDIES ON THE ANTITUBERCULOUS ACTIVITY OF CAPREOMYCINAnnals of the New York Academy of Sciences, 1966