Re: Dietary Folate Consumption and Breast Cancer Risk

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Abstract
Alcohol may increase folate requirements, and low folate intake has been associated with a moderately increased risk of breast cancer in women with relatively high alcohol intake in a Canadian cohort study (1), as well as in the Nurses' Health study (2). Other studies, however, showed no consistent association between folate intake and breast cancer risk (3,4). Alcohol drinking is considerably more frequent in Italian women compared with U.S. or northern European women, and a consistent association was found between alcohol drinking and breast cancer risk in Italy (5,6). We decided, therefore, to consider the effect of folate consumption—and its interaction with alcohol—on the risk of breast cancer.