Bacterial glutaminase in treatment of acute leukaemia.
- 29 May 1976
- Vol. 1 (6021) , 1317-1319
- https://doi.org/10.1136/bmj.1.6021.1317
Abstract
A glutaminase-asparaginase enzyme from Achromobacter sp has antitumour activity in vitro and in animals. Glutaminase was administered in doses of 3500-20 000 IU/m2 body surface area/day to six patients with acute lymphoblastic leukaemia (ALL) and three patients with acute myeloid leukaemia (AML). The enzyme had a blood half life of 80 minutes but depletion of blood glutamine persisted for 12 hours after single doses. Seven patients, including four (two with AML and two with ALL) resistant to asparaginase, received repeated doses of glutaminase. Antileukaemic effects were observed in all seven; one elderly patient developed metabolic acidosis. Study of this new antileukaemic agent in patients with acute leukaemia at an earlier stage of their disease is now justified.Keywords
This publication has 15 references indexed in Scilit:
- Antineoplastic and toxic effects of Acinetobacter and Pseudomonas glutaminase-asparaginases.1974
- Therapy with Erwinia l-asparaginase in children with acute leukemia after anaphylaxis to E. coli l-asparaginaseCancer, 1974
- Effect of Asparagine and Glutamine Deficiency on Normal and Leukemic Cells 2JNCI Journal of the National Cancer Institute, 1973
- PROLYMPHOCYTIC LEUKÆMIA OF B AND T CELL TYPEThe Lancet, 1973
- Isolation, Crystallization, and Properties of Achromobacteraceae Glutaminase-Asparaginase with Antitumor ActivityJournal of Biological Chemistry, 1972
- Effect of L-Glutaminase on Transformation and DNA Synthesis of Normal LymphocytesActa Haematologica, 1972
- In vitro Cytocidal Effect of L-Glutaminase on Leukaemic LymphocytesNature, 1971
- L-AsparaginaseAnnual Review of Medicine, 1970
- E. coli L-asparaginase in the treatment of leukemia and solid tumors in 131 childrenCancer, 1970
- IN VIVO AND IN VITRO EFFECTS OF L-ASPARAGINASE FRACTION OF GUINEA PIG SERUM ON 6C3HED ASCITES LYMPHOSARCOMA1966