THE EFFECTS OF AMRINONE ON TRANSPORT AND CYCLIC-AMP METABOLISM IN TOAD URINARY-BLADDER

  • 1 January 1981
    • journal article
    • research article
    • Vol. 216  (2) , 220-224
Abstract
Amrinone [Win 40680 (5-amino-3,4''-bipyridin-6(1H)-one)] is a new noncatechol, nonglycoside agent with cardiotonic and vasodilator properties. The effects of amrinone in the total urinary bladder, a tissue whose function may be altered by many factors which change cardiovascular activity was studied. Amrinone enhanced the effect of vasopressin and cAMP on water and urea permeabilities and the effect of vasopressin on Na transport. Consistent with the actions, amrinone inhibited cAMP phosphodiesterase activity in epithelial homogenates and increased both cAMP content and the protein kinase activity ratio measured in intact epithelial cells. The inhibitory effect of amrinone on phosphodiesterase may be relevant to its cardiostimulatory and vasodilator activities.