Plasma Substance P Levels in Normotensive and Hypertensive Subjects

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Abstract
Since substance P is a potent natriuretic, diuretic and vasodilatory peptide, a radioimmunoassay for substance P was developed, and its levels measured in the plasma of normal subjects and patients with essential hypertension. The plasma substance P levels were 186 .+-. 14 pg/ml in normal subjects and 164 .+-. 3 pg/ml in hypertensive patients. When the Na content of their diet was reduced to 10 mEq/day, substance P levels failed to change. Plasma renin activity and urinary kallikrein increased. An acute saline infusion failed to alter plasma substance P levels. Assuming an upright posture increased plasma renin activity, but not substance P, in both groups of subjects. Substance P apparently is not involved in the control of blood pressure, kallikrein excretion or renin release in man.

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