Opportunities for pharmacological intervention in the ras pathway
- 1 March 1995
- journal article
- review article
- Published by Elsevier in Annals of Oncology
- Vol. 6 (suppl_1) , S63-S68
- https://doi.org/10.1093/annonc/6.suppl_1.s63
Abstract
The delineation of a ras -dependent signalling pathway from tyrosine kinases to mitogen-activated protein kinases, which is common to a variety of effectors of cell proliferation, suggests that this pathway may provide targets for agents to inhibit cell proliferation. Considerable investigation is needed to determine which points of the pathway are the most suitable for inhibition in terms of effectiveness and selectivity. The use of interfering mutants derived from each component in the pathway is one approach to determining at which point it is best to inhibit.Keywords
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