Thymosin Therapy Creates a “Hassall”(?)

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Abstract
Complete acceptance of transplanted organs can easily be accomplished without the need for immunosuppression in patients who lack a thymus gland. In these cases, then, the defect allows a simple cure. It was predicted in 1968 that isolated thymic (T-cell) deficiency would easily be cured by thymus transplantations.1 In fact, this prediction was realized shortly thereafter in two patients with the embryonic thymus syndrome of DiGeorge.2 , 3 Interestingly enough, the establishment of a long-lived dividing population of T cells of donor origin was not shown in either case. This observation, combined with the rapid return to normal of peripheral blood lymphocyte . . .