Indirect hemagglutination employing enterobacterial common antigen and Yersinia somatic antigen: a technique to differentiate brucellosis from infections involving cross-reacting Yersinia enterocolitica

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Abstract
The existence of enterobacterial common antigen in Y. enterocolitica and its absence in Brucella abortus were utilized to provide a method to distinguish Brucella infections from infections with cross-reacting Yersinia. The indirect hemagglutination test was employed. In experimental laboratory animals [guinea pig, mouse, rabbit], the presence of anti-enterobacterial common antigen was indicative of prior exposure to Y. enterocolitica rather than B. abortus. In cattle, low titers of anti-enterobacterial common antigen were present in all animals. Anti-enterobactieral common antigen titers equaled or exceeded anti-Yersinia O titers in Yersinia-exposed animals; in animals infected with B. abortus the anti-Yersinia O titer generally exceeded the anti-enterobacterial common antigen titer.