The effect of two synthetic steroids on the ultrastructure of the liver of Rattus norvegicus L.

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Abstract
Flumedroxone acetate and an analogue [17-acetoxy-3β(β-carboxypropionyloxy)-6-trifluoromethylpregn-5-ene-20-one] each produce a liver weight increase and a change in hepatic cell ultrastructure, following chronic administration in mice and rats. In all liver cells there is much proliferation of the smooth endoplasmic reticulum, which arises from the ergastoplasm, or rough membranes. An effect on esterase enzyme specificity and the evidence for the induction of an esterase isoenzyme after treatment with these steroids, is referred to. The distribution of the new smooth endoplasmic reticulum is of interest as it varies with each analogue.