Prevention of Prostate Cancer with Finasteride

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Abstract
To the Editor: One perplexing finding of the Prostate Cancer Prevention Trial (July 17 issue)1 is that more high-grade tumors were detected in the finasteride group than in the placebo group. It is hard to put this finding into perspective because of the limited published data on the effects of finasteride on prostate cancer. Yang et al. have reported on a series of needle biopsies of the prostate in men treated with finasteride.2 No significant differences were seen between the treatment group and the control group with respect to multiple variables, including the Gleason grade. However, their study was nonrandomized . . .