Scale‐up of antibiotic fermentations by control of oxygen utilization

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Abstract
Oxygen Utilization as a scale‐up parameter is evaluated in two antibiotic‐producing fermentations. This method of scale‐up was used in tank‐to‐tank and in flash‐to‐flash scale‐up studies. Antibiotic yields and cell weight trends were generally duplicated in the replicate runs, with some discrepancy noted in chlortetracycline yields at high aeration levels. The apparatus for measuring oxygen consumption rates and for automatically controlling oxygen utilization, according to a predetermined pattern, is described.

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